The New World is the main setting of Biomutant. In the center of the New World is the Tree-of-Life. It is currently in a post-apocalyptic setting as the Tree-of-Life is being poisoned by oil, which is causing Bio-Creeps to infest the world.

Areas such as arctic areas, deserts, and a matching underworld are in the New World. A notable point in the new world is Spot-Spot.

The temperature of the New World will fluctuate over time and in different locations, usually it is colder at night and hotter during the day. The envirorment can change due to this, for example water can freeze at cold temperatures.